RESEARCH








General

Conference on Lead Poisoning Prevention & Treatment, Banaglore, India

February 8-10, 1999

INTRODUCTORY REMARKS BY ORGANIZER & HOST

Dr. Abraham M. George

His Excellency, the Governor of Karnataka, distinguished speakers and panelists, ladies and gentlemen. I am honored to stand before this distinguished gathering to make a few introductory remarks on lead poisoning. Before I do so, I want to express my profound gratitude and appreciation to all of you for partaking in this important event. Many of you have traveled far distances, some from the other side of the globe, and that in itself is a true affirmation of your commitment to this cause.

I must start with a nice word about Lead. Lead is a wonderful metal – in fact, a strategic one – and it has a variety of uses, when handled wisely. But lead is also one of the most toxic metals to humans. It does not belong to our body even at very low levels. With elevated levels of lead in our system, lead influences brain development, and affects the proper functioning of organs such as kidney and liver. Children in their early years absorb lead 5 to 8 times as much as adults. Consequently, lead poisoning has become the biggest environmental disease affecting urban children in developing countries.

Recognizing the dangers of lead poisoning to our children and others, The George Foundation embarked 2 years ago on the first major study in India to determine the blood lead levels among our urban population across the country. The study was appropriately named Project Lead-Free. Using the most advanced equipment and adhering to international protocols on screening, the foundation completed 22,000 blood tests in 7 major cities. Today, we are making the results of this study available to the general public.

I am afraid I do not have a happy story to tell. In fact, I have an alarming story to tell you. Project Lead-Free study has concluded that over 50% of the nation’s children below the age of 12 living in urban environments have unacceptable blood lead levels of 10 micrograms per deciliter or more. Further, 14% of the children in our cities have seriously elevated levels of lead of 20 m g/dl or more. When we consider the 100 million or so of our children living in urban areas, the numbers behind these statistics are staggering.

At the risk of being termed an alarmist, I have no other way to say that we have an environmental health crisis in the making in India. The evidence is clear. With all humility I must say that it is a national disgrace that we have collectively allowed lead poisoning to affect millions of our children and others. If unchecked, millions more of unborn will fall victim to lead poisoning in the future.

What does this mean for our future workforce? Allow me to make a few simplifying assumptions to translate the impact of lead poisoning to monetary terms. If we assume that the average annual productivity of the urban worker in India is Rs. 120,000 (i.e. Rs. 10,000 per month, which is, by the way, only 1/10th of that in urban America), and also assuming a direct correlation between loss in IQ and productivity, i.e., if we have an elevated level of 10 to 20 m g/dl, there would be 4-5% decline in IQ, and hence 4-5% decline in productivity. Someone may argue about this assumption, but I believe it is only a conservative assumption supported by scientific evidence. We can now estimate the cost to the nation when our present children enter the workforce. Simple arithmetic tells you that this cost is no less than Rs.300 billion per annum. As the urban population increases over time, this cost also increases exponentially if we do not take effective measures to check the problem.

In today’s global economy where India hopes to compete in the fields of computer technology, communication and other specialized fields, can we afford to have future generations of our workforce below their full intellectual potentials? I don’t need to answer this question --- the answer is obvious to all.

During the next 3 days, all of us will discuss the problem with one single goal – to find practical solutions to deal with the problem. We will bring together our expertise and experiences to develop a comprehensive plan that can be implemented at national levels for the prevention and treatment of lead poisoning. The world’s leading scientists on the subject have gathered here under one roof to find solutions that developing countries can apply. This conference will present concrete solutions that must be implemented. The time has come to act. We cannot wait any longer.

Each one of the constituencies in our society has a role to play in the solution. Hopefully, this will not be simply another government undertaking. Both public and private sectors, as well as all of us as parents and citizens must work together. I hope we will have the courage and the determination to do so.

Thank you.

 

REMARKS BY PRIMARY SPONSORS

Richard Ackermann, The World Bank

Distinguished delegates, ladies and gentlemen. On behalf of the Vice President, Meiko Nishimuzu from the World Bank, it is indeed a pleasure and honour to welcome all of you here.

It is an honour because all of the key experts on the issue are here, and there are delegates from nine neighboring countries, so this is truly a regional event, which I am sure, will yield results. We are pleased to co-sponsor such an important event on a topic to which we have tried to draw attention now for several years because we attach indeed a lot of importance to it. It is a serious problem but we also think there exists cost effective solutions so it is not just a problem about which one will have wishful thinking but it is a problem to which we can really move forward towards solutions.

This conference fits well with our role of the World Bank to help facilitate solutions to critical development problems. It is also consistent with our view that solutions require broad approaches. Scientists, doctors, politicians, government officials, industry leaders from private and public sectors and NGO’s will all need to contribute to solutions for this problem.

Solutions will range anywhere from medical testing, to urban planning, tax policies, and even privatisation. So indeed the agenda is quiet large. Let me congratulate Dr. Abraham George and the organisers for this quiet spectacular event to which they have managed to bring so many big names.

Lead poisoning affects specially children, as Dr. Abraham George just said a moment ago. I think the great thing of about this meeting is that it is increasing the opportunities. Opportunities for the future generation to contribute to a better world and I think this is the most worthy cause that we can think of.

Thank you very much.

 

Dr. Henry Falk, Centers for Disease Control and Prevention

Thank you very much, His excellency the Governor, Dr. George, Admiral O.S. Dawson and my colleagues from participating sponsoring organisations and my welcome to all of you as delegates at this meeting.

CDC is very proud to be a co-sponsorer of this meeting and this has been a high priority for us as we have worked and planned for this day and this conference. Speaking for myself but also for Dr. Jackson who heads our Center for Environmental Health at CDC and for Dr. Copeland who is the Director of CDC, all of us have been here before to India, and now this is my 6th trip. Both Dr. Jackson and Dr. Copeland have been here before and we have all come to share with joint interests in seeing a successful conclusion to this meeting. The initial impetus came from Dr. George himself and I hope that Dr. George will sometime in this meeting recount for you how he became interested in Lead Poisoning. He literally re-invented the wheel, as we say, and came from his background, which is not medical or public health, to understanding the concerns about Lead Poisoning and the potential threat to the children. The value that could be gained from this effort is tremendous, and so let me extend my commendations to Dr. Abraham George for his efforts.

Several of us participated last year at a workshop on heavy metal toxicity in Lucknow, India, which was co-sponsored by Industrial Toxicology Research Center, EPA and CDC and we received some first hand information, very early information on the potential problems related to lead exposure within India. We received just the very earliest meaningful data, very limited, heard more environmental data, but also gained appreciation for the problems that lay ahead enduring with this illness in India. Problems such as difficulty in treating children, and the need for more pharmaceutical agents, lack of laboratory monitoring equipment for measuring blood lead levels and so on. There are many impediments at the moment for dealing with this problem, but hopefully this particular meeting can provide a springboard to developing solutions.

At CDC we have had a domestic programme in the US for the past 20-30 years dealing with Lead Poisoning, but with particularly within the last 2-3 years we have had increasing involvement in international affairs related to Lead. We have had projects in the last several years in Russia, China, India, and the Middle East including Egypt as well as other countries in Latin America including Mexico, Peru and Brazil.

So we have begun to appreciate the diversity of Lead problem as it exists worldwide. Yes, leaded gasoline is a very important problem but there are many other sources, many of which are in very concentrated forms that can lead to high exposures. So we have to appreciate the particular types of exposures and the nature of the problem that exists in each country.

I am greatly encouraged by being able to participate together with the World Bank, WHO and EPA and all the Indian sponsors. I think that this could be a landmark for India, as well as the start of programme for global eradication of Lead Poisoning. There are many US colleagues who are here; they have battled very hard in the US for over the last 20-30 years to eliminate childhood Lead Poisoning. I hope they would be able to contribute as the conference moves along and be able to participate in whatever way they can to help you in working on the problem here in India.

You know all of us as scientists, we think of time as a continuum, -- there are seconds and more seconds, hours, weeks, months, -- time merges in one moment and leads to the next. One moment is no different than the next in some quantitative sense. However all of us thinking of our lives and thinking from our hearts and minds know that there are always grand moments in history. There are key moments in history highlights that always stand out from all the others because they change the way we look at things, and because they enable new things to happen as they energize you to some surge of creativity. So my hope that these days we spend here together will be such moments, and that they will start an effort leading to the greater good both here in India as well as else where in the world.

Thank you.

 

Mr. William A. Nitze, U.S. Environmental Protection Agency

Thank you Governor, Admiral, Dr. Abraham George, colleagues, ladies and gentlemen. It is a great honour for us at the U.S. EPA to participate in this important conference and serve as one of the sponsors. It took me a long time to get here as it did for many of you. It was a very long trip but I and the agency that I represent, the US-EPA, are committed to eradicating the silent hazard that is the Lead Poisoning. Why? Because in my country and in your country Lead Poisoning is a major public health problem, and a problem that is particularly severe for the children. Lead is insidious, you cannot see it, smell it or even taste it but it is there. It accumulates in the body and long term consumption of even very low levels is as dangerous as a single concentrated ingestion. It has been almost 30 years since the US began to phase lead out of gasoline. It has been little more than 20 years we banned the use of Lead in Paint. Our food industry has stopped using lead-soldered cans. Yet in 1996 there still estimated to be 1.7 million children that had blood lead levels that exceeds the allowable level of 10 ug/dl. I am happy to say that this number fell to 890,000 last year.

However this number still represents 4.4% of our children in the US, and must be reduced further. Our biggest single problem is still lack of knowledge about Lead. In low levels of Lead Poisoning there are no symptoms and there is no treatment and we cannot assume that there are no effects. This conference will go a long way to address the lack of knowledge and information regarding the silent threat by providing opportunities for leaders in the field to discuss the problem of Lead Poisoning and identify sound strategies to prevent this disease. We can perhaps convince our leaders to take concrete action. In our own work at EPA, we struggle daily with the issue of achieving concrete measurable improvements to our environment. If the work of this conference serves to save one child’s life, all of us here would have met this challenge for today.

I challenge this distinguished group of experts from around the world to end this 3 day conference with a concrete plan of action that we can undertake here in India and in each nation represented to ensure that children will no longer bear the unfortunate burden.

In closing let me thank Dr. Abraham George and The George Foundation for this initiation in organising this conference and I sincerely hope that their enlightened effort is the beginning of a process focussed on eradicating the vicious silent yet completely preventable disease.

Thank you very much.

 

Dr. Yasmin von Schirnding, World Health Organization

Thank you, distinguished delegates and attendees. On behalf of the WHO I wish to welcome you to this important International Conference on the Prevention and Treatment of Lead Poisoning. I would also like to express the sincere regrets of Ms. Poonam Khetrapal Singh, Executive Director of Sustainable Development and Healthy Environment at WHO, who is unfortunately unable to be with us today. But she has asked me to read a statement on her behalf.

In particular I thank the organizer, especially The George Foundation, in taking the initiative in putting together the stimulating and innovative programme. The surveillance that has been undertaken here in India is truly extraordinary. We congratulate you on your efforts and hope that this important initiative will help to stimulate further awareness of the public health impact of Lead Poisoning throughout the world, most particularly in developing countries.

WHO has long considered Lead Poisoning to be a key preventable disease of immense potential public health impact. Worldwide human exposure to Lead remains an important issue whether the sources are in the workplace, the home environment, or community environment at large. Lead is the one of best-studied toxic substance, the health effects of which we probably know more about than virtually any other chemical. It’s ill health effects have been well documented across extremely wide range exposure right down to very low levels approaching the very limits of detection. The very young, the poor and occupationally exposed are normally most at risk. Over many years WHO has been actively involved in initiatives aimed at obtaining better understanding of the problem in all its dimensions from the toxicology and epedimiology of clinical and sub-clinical Lead Poisoning to measures associated with its prevention and control. This conference provides a unique opportunity to draw on the shared experiences and lessons learned from many different organizations and countries with varied perspectives and insights into the nature of the problems faced.

I hope that your discussions here during the next few days will help to influence relevant regulations and policy issues so that current and future generations will be protected against one of the insidious environmental health problems that has plagued us for so long.

I wish you well in your deliberations.

Thank you

 

ADDRESS BY CHIEF GUEST

Shri. Khurshed Alam Khan

Governor of Karnataka

Dr. George, Admiral Dawson, Mr. Ackermann, Mr. Nitze, Dr. Falk, Dr. Schirnding and distinguished participants. At the outset I would like to welcome the participants to our city. On behalf of myself and the Government of Karnataka I welcome you all. I hope you will be very busy for next 3 days in your deliberations but still be able to find little time to see our garden city. I hope you would all take back very good memories when you go home from here.

It is my proud privilege to associate myself with today’s function to inaugurate the Conference on Lead Poisoning: Prevention and Treatment organized and sponsored by The George Foundation, the Centers for Disease Control and Prevention and Environment Protection Agency (USA), World Health Organization and The World Bank.

Pollution problems had their beginning with the growth of cities and rapid urbanization combined with high degree of industrialization. Over population and pollution have wrecked havoc in big cities the world over. Technological advances in industry and agriculture introduced thousands of new chemicals including fertilizers, insecticides, and herbicides, many of which naturally run off into the rivers, atmosphere and ecosystem. A range of diseases hitherto unknown to human population is throwing up challenges to human existence. This has brought in its wide environmental and social problems. The fruits and vegetables we eat everyday are sprayed with lethal pesticide over a number of years. This contamination can have serious side effects like paralysis, kidney trouble and even cancer.

Lead Poisoning is the number one environmental pollutant effecting the health and well being of 2/3rd of the world’s children in urban areas. Our statistics indicate the lead pollution in our environment have reached alarming levels by inadequately controlled industrial emissions and insemination of leaded gasoline, which when burnt in automobile engine is the major source of lead in urban areas in India. Though we have issued our first national emission standard for Lead and other pollutants in 1990, our main source of lead pollution continues to be through automobile exhaust. The constantly increasing number of automobiles on the road is one reason and the other is that our recommended permissible limits of lead and carbon monoxide are still very much higher than those of developed countries.

Long term consumption of low levels of lead is said to be dangerous causing learning disability, decline in IQ and even permanent brain damage. Children and pregnant women are particularly susceptible to lead poisoning. Lead poisoning causes anemia, blood pressure in both children and adults, and paradoxically it is like a vicious circle as deficiency of iron, calcium, zinc causes absorption of lead.

Bangalore has emerged as the fifth largest metropolis in the country and its population has reached to a phenomenal 5 million mark from just 0.4 million in 1991. Congestion, over crowding, vehicular pollution and lack of basic amenities made Bangalore once boasting as the garden city of India, relic of what it was a few decades ago. Awareness of about the importance of keeping our environment clean and pollution free among the people and especially among the industrialists is important. Polluting the living environment must be punishable; most stringent enforcement of available rules is also necessary. In addition to this we must take steps to make mandatory the use of lead-free petrol by all automobiles.

I congratulate The George Foundation for having taken this initiative to sensitize and create awareness among the public about the ill effects of lead pollution and also for creating an excellent platform to scientists and scholars in the field of health and environment. It has permitted leading industrialists around the world to meet, discuss and share their ideas on the public health hazards.

I hope and wish that these deliberations will be fruitful in arriving at tangible solutions for the problem and help in formulating the national plan, and in improving existing plans for the prevention and treatment of lead poisoning.

Thank you.

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